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Gut With Firmicutes and Bacteroidetes Bacteria

Intestine with Firmicutes and Bacteroidetes micro organism. Credit score: © CMFI/Leon Kokkoliadis

A Low-Calorie Weight loss program Alters the Intestine Microbiome and Delays Immune Ageing

A calorie-reduced food plan can not solely delay the event of metabolic ailments, but in addition has a optimistic impact on the immune system. Researchers have now proven for the primary time that this impact is led to by an altered intestine microbiome, which slows down the deterioration of the immune system in outdated age (immune senescence). The analysis examine has been revealed within the journal Microbiome.

Intestine microbiome

The intestine microbiome is the time period used to explain the totality of all microorganisms and intestinal micro organism in our digestive tract. Amongst different issues, it influences the immune system and the metabolism of its host.

Round 2 billion individuals worldwide are obese. Weight problems will increase the danger of growing hypertension, coronary heart assault or kind 2 diabetes mellitus. It may possibly additionally trigger irritation within the physique that weakens the immune system via an accumulation of particular reminiscence T and B cells. This course of is known as immune senescence, an age-related change within the immune system.

In overweight individuals, a low-calorie food plan can delay the event of metabolic sicknesses comparable to kind 2 diabetes. Moreover, such a food plan is useful to the immune system. Nevertheless, it’s unclear precisely how the optimistic results are led to and what perform the intestine microbiota performs on this course of. Researchers have now explored the relationships between calorie-reduced diets, the microbiome, metabolism, and the immune system in a brand new examine.

Calorie-reduced food plan alters the intestine microbiome

For this objective, they first analyzed how a really low-calorie food plan (800 kcal/day for 8 weeks) affected the intestine microbiome of an overweight lady. Within the subsequent step, the researchers transplanted the intestine microbiota earlier than and after the food plan intervention into germ-free mice to ascertain a gnotobiotic mouse mannequin. “On this method, we have been in a position to decide the only results of the diet-shaped intestine microbiome on metabolism and the immune system,” mentioned Reiner Jumpertz-von Schwartzenberg, final creator of the examine and a scientist on the Institute of Diabetes Analysis and Metabolic Ailments of Helmholtz Munich on the College of Tübingen, a accomplice of the German Heart for Diabetes Analysis (DZD). He led the examine along with Hans-Dieter Volk and Joachim Spranger of Charité.

Weight loss program-altered intestine microbiome improves metabolism and delays immune senescence

By transplanting the diet-altered microbiota, glucose metabolism improved and fats deposition decreased. As well as, mass cytometry confirmed that the extent of particular reminiscence T and B cells was additionally lowered. “This means delayed immune senescence,” mentioned Julia Sbierski-Type, first creator of the examine.

“These findings recommend that the optimistic results of a low-calorie food plan on metabolism and the immune system are mediated by way of the intestine microbiome,” Sbierski-Type mentioned. Nevertheless, the authors of the examine emphasize that the investigation has thus far solely been performed with the microbiome of 1 individual and that the experiments must be repeated with extra topics to verify the outcomes. The brand new findings may be fascinating for medical apply in the long run. “An improved understanding of the advanced interaction between food plan, the microbiome, and the immune system might set the stage for the event of latest microbiome-based therapeutic avenues to deal with metabolic and immune ailments,” mentioned Jumpertz-von Schwartzenberg.

Reference: “Results of caloric restriction on the intestine microbiome are linked with immune senescence” by Julia Sbierski-Type, Sophia Grenkowitz, Stephan Schlickeiser, Arvid Sandforth, Marie Friedrich, Désirée Kunkel, Rainer Glauben, Sebastian Brachs, Knut Mai, Andrea Thürmer, Aleksandar Radonic, Oliver Drechsel, Peter J. Turnbaugh, Jordan E. Bisanz, Hans-Dieter Volk, Joachim Spranger and Reiner Jumpertz von Schwartzenberg, 4 April 2022, Microbiome.
DOI: 10.1186/s40168-022-01249-4

In regards to the examine:

The goal of the examine was to find out the interactions between a calorie-restricted food plan, microbiome and the immune system. To this finish, a human dietary intervention trial was mixed with gnotobiotic experiments during which immunophenotyping was decided by multidimensional single cell mass cytometry. The next institutes and analysis amenities have been concerned:

  • German Heart for Diabetes Analysis (DZD)
  • Institute of Diabetes Analysis and Metabolic Ailments (IDM) of Helmholtz Munich on the College of Tübingen
  • Division of Inside Drugs IV (Director: Prof. Andreas Birkenfeld), Tübingen College Hospital
  • Cluster of Excellence EXC 2124 “Controlling Microbes to Combat Infections” (CMFI), College of Tübingen
  • Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, company member of Freie Universität Berlin, Humboldt College of Berlin
  • Division of Endocrinology and Metabolism, Charité – Universitätsmedizin Berlin, company member of Freie Universität Berlin, Humboldt College of Berlin
  • Berlin Institute of Well being at Charité – Universitätsmedizin Berlin, Movement & Mass Cytometry Core Facility, Berlin


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